狼疮肾脏表达TIM-3可能与病情活动相关

作者:发布时间:2013/12/10 9:53:27

狼疮肾脏表达TIM-3可能与病情活动相关

邢瑞

        摘要  目的:比较系统性红斑狼疮(SLE)患者和非SLE患者肾组织中TIM-3(人T细胞免疫球蛋白结构域和粘蛋白-3)的表达情况,并评价两者之间的TIM-3表达差异。

        方法:本研究总共入选272例SLE患者,62例非SLE患者(对照组),所有SLE患者均接受了经皮肾穿刺活检术。检测肾组织中TIM-3的表达水平以及所有患者的血清学指标,比较两组的TIM-3和血清学指标的差异。

结果:97.1%的SLE患者出现TIM-3染色阳性(272例中264例阳性),而非SLE组有95.2%的染色阴性(62例中59例阴性),在对照组的62例中只有3例为TIM-3染色阳性。在几乎所有反映SLE活动度的血清学指标中,两组间均有显著差异。肾脏病理表现与TIM-3的表达程度呈正相关。在对照组中,TIM-3的高免疫反应性与血清学分级显著相关(p<0.001)。

        结论:SLE患者的肾组织中表达TIM-3,非SLE患者很少表达TIM-3。TIM-3的表达量与疾病“活动度”相关。

        附原文:Abstract: The aim of this study was to evaluate the expression of TIM-3 in renal tissue from patients with systemic lupus erythematosus (SLE) and patients without SLE, and to evaluate the difference of TIM-3 expression between them. A total of 272 patients with SLE as SLE group and 62 patients without SLE as control group were enrolled in the present study. Patients with SLE accepted percutaneous renal biopsy. We examined the expression of TIM-3 in renal tissue and the serological parameters in serum from all enrolled cases. The expression of TIM-3 and serological parameters were compared between the different groups. Positive staining of TIM-3 protein was seen in 97.1 % patients with SLE (264 out of 272), but 95.2 % negative staining in the cases without SLE (59 out of 62), only 3 out of 62 patients in control group were positive staining of TIM-3. There were significant differences between two groups in almost all serological markers which reflect SLE activity. There was a nearly positive correlation between pathological manifestations and expression degree of TIM-3. High immuno-reactivity of TIM-3 was found to be significantly correlated with serological grade (p < 0.001), but there was the phenomenon in control group. The results showed that there was the expression of TIM-3 in renal tissue from the patients with SLE, but rarely expression in cases without SLE. Expression of TIM-3 was associated with the diseases’ activity.

        引自:Ling Guo, Xiangdong Yang, Qing Xia, Junhui Zhen, Xuewei Zhuang, Tao Peng. Expression of human T cell immunoglobulin domain and mucin-3 (TIM-3) on kidney tissue from systemic lupus erythematosus (SLE) patients. Clinical and Experimental Medicine, 2013, doi: 10.1007/s10238-013-0264-3.