血清维生素D水平与RA疾病活动度呈负相关

作者:发布时间:2013/12/10 9:52:08
 血清维生素D水平与RA疾病活动度呈负相关
孙琳 
摘要:目的:类风湿关节炎(RA)是常见的自身免疫性疾病。由于血清中维生素D(Vit D)水平与多种自身免疫性疾病显著相关,因此本研究的目的是明确血清Vit D水平与初诊RA疾病活动度的关系。 
方法:本实验为2012年通过简单抽样进行的横断面研究,共纳入66例符合ACR分类标准的RA患者。收集患者的DAS28评分、血沉、CRP、晨僵时间、关节肿胀数、压痛数。使用化学发光免疫分析法检测血清中25羟维生素D (25(OH)D)水平。数据分析使用 Pearson相关。 
结果:本研究纳入10例(15.2%)男性、56例(84.8%)女性RA患者,平均年龄为(45.2 ± 15.3)岁。患者血清中25(OH)D的表达水平为(30.5 ± 28.9 )ng/mL,DAS28评分为( 5.6 ± 1.1)。相关性分析结果显示血清25(OH)D与DAS28评分、肿胀及压痛关节数、患者整体评价及晨僵时间呈负相关(P < 0.01),但与血沉及CRP无明显相关性。 
结论:本研究结果提示RA疾病活动度与血清维生素D水平负相关,疾病活动度越高的患者血清维生素D水平越低。
 附全文:INTRODUCTION: Rheumatoid Arthritis (RA) is one of the most prevalent autoimmune diseases. Due to the significance of the relationship between serum vitamin D levels and autoimmune diseases, this study aimed to determine the relationship between serum vitamin D level and the severity of disease activity in patients with newly diagnosed RA. METHOD: This cross-sectional study was conducted on 66 patients meeting the American College of Rheumatology - European League Against Rheumatism classification criteria for RA. It was performed in 2012 using simple sampling. The disease activity was measured based on Disease Activity Score of 28 joints - erythrocyte sedimentation rate (DAS28-ESR) and serum 25-OH vitamin D (25(OH)D) levels using the chemiluminescent immunoassay method. In addition, the levels of ESR and C-reactive protein (CRP), the duration of morning stiffness, and the number of joints with tenderness and swollen were calculated as well. The data were analyzed using the Pearson correlation coefficient. RESULTS: In this study, 10 patients were male (15.2%) and 56 were female (84.8%). The average age of the participants was 45.2 ± 15.3 years. The average level of 25(OH)D in the patients' serum was 30.5 ± 28.9 ng/mL and the mean DAS28-ESR was 5.6 ± 1.1. The correlation coefficient showed that there was an inverse relationship between 25(OH)D and DAS28-ESR, the number of tender and swollen joints, global patient assessment and duration of morning stiffness (P < 0.01). However, the average 25(OH)D level was not related to ESR (P = 0.779) and CRP (P = 0.269). CONCLUSION: The results of this analysis indicated that patients with more active RA have a lower serum vitamin D level. 
 摘自:Zakeri Z, Sandoughi M, Mashhadi MA, et al. Serum vitamin D level and disease activity in patients with recent onset rheumatoid arthritis. Int J Rheum Dis.2013 Oct 18. doi: 10.1111/1756-185X.12181. [Epub ahead of print]